For more than 35 years, Teledyne e2v has successfully delivered generations of High Reliability Microprocessors, to worldwide Avionics, Space & Defense customers including Airbus, Boeing, NASA, ESA,… In this paper, we will first list the top needs from Aerospace & Defense customers, then detail how Teledyne e2v Microprocessors are perfectly suited for those High Reliability requirements, prior to a deep dive into the qualification of these High Reliability Microprocessors.